Cellular therapy & immunotherapy is an exciting area of science

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Immunotherapy is treatment that uses certain parts of a person’s immune system to fight diseases such as cancer. This can be done in a couple of ways: Stimulating your own immune system to work harder or smarter to attack cancer cells, Giving you immune system components, such as man-made immune system proteins. Some types of immunotherapy are also sometimes called biologic therapy or biotherapy. In the last few decades immunotherapy has become an important part of treating some types of cancer. Newer types of immune treatments are now being studied, and they’ll impact how we treat cancer in the future.

T-cell is a lymphocyte of a type produced or processed by the thymus gland and actively participating in the immune response.

For years, the foundations of cancer treatment were surgery, chemotherapy, and radiation therapy.


Over the last two decades, targeted therapies that target cancer cells by homing in on specific molecular changes seen primarily in those cells have also cemented themselves as standard treatments for many cancers.

But over the past several years, immunotherapy therapies that enlist and strengthen the power of a patient’s immune system to attack tumors—has emerged as what many in the cancer community now call the “fifth pillar” of cancer treatment.

Scientists are working on a systematic tool kit to engineer what a cell senses and responds to. And if they can begin to apply what they have done in mice to humans, reprogramming cells could become a radical new approach for cancer as well as autoimmune diseases.

STEPS IN CAR-T CELL THERAPIES:

#1: Apheresis/Leukapheres: CAR T cell therapy begins with collection of the patient’s blood and separation of the lymphocytes through apheresis* The procedure is performed at the clinic or infusion center by the patient’s healthcare team.

#2: Transport & Handling:  Once collected, the lymphocytes are immediately packaged by the clinic or infusion center for hand delivery to a centralized manufacturing facility. The full manufacturing process can take from 10 days to several weeks to complete.

II of iV: natural serial killer: in action

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Ii of iV : the programmed serial killer: chimeric antigen receptors (C.A.R.s)

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III of IV: James Allison's Cancer Research Breakthrough

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IV of IV: AT First..

#3:  Cell Engineering : The CAR T cell manufacturing facility is responsible for post-apheresis processing, activation, transduction, and expansion of the CAR T cells.

#4: CAR T Infusion: The patient’s healthcare team administers the prepared CAR T cell therapy. The infusion process usually takes about 1 hour, but some patients may need to remain in the hospital for a number of days.

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